Expedition 64 was an International Space Station increment commanded by Roscosmos cosmonaut Sergey Ryzhikov. It began on October 21, 2020, after Soyuz MS-16 undocked and left Ryzhikov, Sergey Kud-Sverchkov, and Kate Rubins as the resident crew. SpaceX Crew-1 reached the station in November with Michael Hopkins, Victor Glover, Soichi Noguchi, and Shannon Walker, expanding Expedition 64 into one of the early regular Crew Dragon rotation increments. The crew supported station research, maintenance, cargo operations, Russian-segment work, and U.S. segment EVAs, while also operating during the COVID-era transition to more routine commercial crew transportation. The increment later entered a Soyuz MS-18 handover period when Oleg Novitsky, Pyotr Dubrov, and Mark Vande Hei docked on April 9, 2021. That handover briefly brought the Expedition 64 crew to ten people before Ryzhikov, Kud-Sverchkov, and Rubins departed on Soyuz MS-17. Expedition 64 ended on April 17, 2021, when Soyuz MS-17 undocked and command passed to the Expedition 65 crew.