Expedition 65 was an International Space Station increment that began after Soyuz MS-17 undocked on April 17, 2021. The first resident crew combined the departing Crew-1 astronauts Shannon Walker, Michael Hopkins, Victor Glover, and Soichi Noguchi with the Soyuz MS-18 crew of Oleg Novitsky, Pyotr Dubrov, and Mark Vande Hei. Walker began the increment as station commander, then handed command to JAXA astronaut Akihiko Hoshide after SpaceX Crew-2 arrived. Crew-2 brought Shane Kimbrough, Megan McArthur, Hoshide, and ESA astronaut Thomas Pesquet to the station, replacing Crew-1 after Dragon Resilience departed in early May. During the increment the crew supported station science, cargo operations, Russian-segment maintenance, commercial crew rotation work, and several U.S. and Russian spacewalks. The mission also included major handovers on the Russian segment, including continuing Nauka-related work after the module's arrival period. In early October, Hoshide handed command to Pesquet, who became the station's first French commander. Soyuz MS-19 then docked with Anton Shkaplerov shortly before the increment ended. Expedition 65 concluded on October 17, 2021, when Soyuz MS-18 undocked with Novitsky, Klim Shipenko, and Yulia Peresild, beginning Expedition 66 under Pesquet.