Expedition 66 was an International Space Station increment that began on October 17, 2021, after Soyuz MS-18 undocked. Thomas Pesquet initially commanded the station during the transition from Expedition 65, with Pyotr Dubrov, Mark Vande Hei, Anton Shkaplerov, Shane Kimbrough, Megan McArthur, and Akihiko Hoshide aboard. Shkaplerov took command on November 6, and SpaceX Crew-2 returned shortly afterward. The core six-month crew arrived when SpaceX Crew-3 brought Raja Chari, Thomas Marshburn, Matthias Maurer, and Kayla Barron to the station in November 2021. The increment supported station research, cargo vehicles, Crew Dragon operations, Prichal and Nauka-related Russian segment work, and several spacewalks across both the U.S. and Russian segments. Soyuz MS-21 docked in March 2022 with Oleg Artemyev, Denis Matveyev, and Sergei Korsakov, bringing the first all-Roscosmos Soyuz crew to the ISS in years and starting the handover into Expedition 67. Expedition 66 ended on March 30, 2022, when Soyuz MS-19 undocked with Shkaplerov, Dubrov, and Vande Hei.